I don't think it'd be easy considering the speeds you expect from the various buses. You could put everything on a PCIe card and let it drive a backplane through a specialized connector, but that wouldn't be like S-100.
A couple weeks back I was thinking about building a backplane that would allow a bunch of BBC Microbits to cooperate. That, too, would not be like an S-100 bus.
A couple weeks back I was thinking about building a backplane that would allow a bunch of BBC Microbits to cooperate. That, too, would not be like an S-100 bus.