Yes, I have 2009 Mac Pro (which cost me all of $300 on craigslist, and now also has 32GB of ram, raided SSDs, and GTX 750Ti ) with a usb3 card in it that works just fine. That said, I have Gnome 3 on my laptops and I find it be pretty practical, too.
FYI there are macOS compatible PCI-E USB 3 cards available. Apparently some of the newest USB-C PCI-E cards work too though I haven't tried it myself.