Maybe for some? I had been using an "ergonomic" Microsoft keyboard for years, but found that it was the amount of force and distance to depress a key that was causing me problems.
I'm using the Microsoft Sculpt keyboard at work at the moment, which has a similar ergonomic layout but less travel than my old Natural. It's also really nicely made (magnetic stand + battery cover, and fairly sleek design).
However, one fairly significant issue is that the top row uses buttons instead of keys. It doesn't bother me too much, but I can imagine that would mess with some people's workflows. Also the corresponding "ergonomic" mouse was the worst I've ever used. It's like a large ball that forces me to stretch and grip constantly to keep my fingers on the buttons. I replaced it almost immediately.
