Personally i prefer to disable antialiasing and if possible use bitmap fonts designed for clarity. Sadly almost nothing supports properly bitmap fonts these days (assuming it supports them in the first place - i think only GDI and X11 core does, but those are increasingly ignored by programs) and even when you can find support, finding good bitmap fonts is hard because it looks like most bitmap fonts are converted from outline fonts - but with jaggies.

As for what i consider a good bitmap font, in Windows MS Sans (the one you could find in Win9x, it was removed in later versions of Windows and aliased with MS Sans Serif which is an outline font), plain Courier and Fixedsys. On Linux i like the console font that you get when booting Debian (not sure what is called) as well as the Terminus fonts. On X11 i like the helv* fonts (usually registered as adobe helvetica - honestly, why is font registration on Xorg such a clusterfuck?) and some of the Fixed fonts (the smaller ones mainly, the larger are a bit too jaggy). On Mac... pretty much all of the original Macintosh fonts. I also like the "WarpSans" font that OS/2 (and eComStation) has, it is very compact and i like compact fonts (although i'm not fan of a few details, like the w being a bit too jaggy).