While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger.
I'm seriously considering it in a few years after it has more time to be proven safe enough.
For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methylation can be measured cheaply as well, I don't see a reason why not to.
> I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger.
If you have any ready-researched and outlined sources or links for this, please post them here for reference. I know that we all can google, but I think linking here will help a lot of people, me included. HN articles are sometimes used as an online notepad of sorts, a repository of well researched and compiled information with built-in peer review from (hopefully, since they are on HN) somewhat competent even if amateur internet researchers.
Not only is HGH regulated, it even is specifically addressed under law (in the US) that lead some to believe that even prescribing it off-label it is illegal. See:
Maybe you know this, but:
Interpreting DNA methylation isn't straightforward. Since it's involved in gene regulation and cell differentiation, it's variable across cells. Due to regulatory networks, whether any particular methylated region is responsible for some outcome may also be unclear.
That being said, if you have reason to believe that the knowledge will help, or are just curious, feel free
sure, I understand that, but from what I saw the data isn’t that hard to process either, there are multiple R libraries actually that help, I’m currently also learning Genomics Analysis Harvard course at edx.org.
I already found multiple papers published in the last few years that identified the important locations with methylation changes, and those targets map to known illneses.
I tried to go to many doctors, but as they couldn’t measure any important changes with their toolboxes, they all sent me to psychologists.
Thanks for offering help, I’m always interested in learning more about genomics, though right now my plan is to learn by reproducing some articles that I read that contain methylation data sets (after the Harvard course).
I’m going to give the strong recommendation of NOT supplementing HGH ever unless your physician advises it. HGH is a potential trigger for cancer, onto of how it is a potent anabolic hormone that will enlarge all your organs. Unless you have certain medical conditions, there is very little reason for one needing HGH.
What makes you think NMN has been "proven to be safe?" That's a pretty strong standard to conform to. There's virtually no clinical work that's been done at all, for starters.
HGH being Human Growth Hormone? I've taken that during puberty, as a medium to get to "normal size"
In hindsight doctors say that might have been what triggered my chronic auto immune hepatitis (immune system attacks my own liver). They say basically they don't know and will probably never know, but it has been put forth as a possible trigger.
chances are you had your dna genotyped, not sequenced, if it was cheap. measuring your methylation patterns is not going to be cheap as you need to sequence your dna twice to see what has actually been methylated. i'm not sure if any companies are offering a consumer targeted panel approach.
I’m planning to do 450k or EPIC BEADS chip, not whole epigenom sequencing, as most researchers used 450k chip for finding the interesting methylation differences for people affected by high air pollution. I saw about $500/sample, but if it’s significantly more, it’s not a problem for me, my chronic disease isn’t going away anyways.
> I already got my DNA sequenced, but now that methylation can be measured cheaply as well, I don't see a reason why not to.
Are they just quantifying how many methyl groups are attached to a piece of DNA? Methylation is a mechanism for site-specific in/activation, so I'm unclear (and curious) how this would be useful.
I'm seriously considering it in a few years after it has more time to be proven safe enough.
For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methylation can be measured cheaply as well, I don't see a reason why not to.