What kind of a question is that? Of course there are, and self-hosting does not replace key verification.

- Wire

- Signal

- Jami

- Matrix/Element with central servers

- Threema

- Briar

- WhatsApp if you turn on key change notifications

- even Telegram secret 1:1 chats on a client that supports these kinds of chats

- anything you add OTR or PGP to... and the list goes on

You just need to do key verification, since key distribution is an unsolved problem in cryptography.