Not sure that it's game-breaking, depends on how you define the game. For example, I think that humans can't exterminate all insects [1], or bacteria[2] alive. However the other way around I'm not so sure.

1. https://www.si.edu/spotlight/buginfo/bugnos

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991899/