People start to care when they get deeper into the graphic design rabbit hole and basically express their work through type and its character exclusively, like in logo design, poster design etc. where type character has a big impact on the individual letter level.

Body and sub-heading text is a bit more forgiving and less detail thirsty, the focus is more on the texture of textblocks rather than the individual letter or words.

If you have to cut up and modify individual letters, Helvetica can be quite nice to work with.