I had a similar issue, wore a wrist brace for years - my solution was to switch to a laptop with a trackpad - the continual moving my hand to the right to a mouse or trackball was what was doing it - I haven't owned a desktop machine for over 20 years now
I would like a ThinkPad shaped keyboard with mousepad and trackpoint included (the mousepad below the spacebar and mouse button both above and below it)
almost every mouse/keyboard combo has the mousepad on the side which I dislike