I love a certain subset of Perl with a passion bordering on mania. While I wouldn't call it domain specific, I do think it's better defined by the domains it's not well suited for. I wouldn't use Perl for GUI programming for example.
> I wouldn't use Perl for GUI programming for example.
I would. I used the gtk-perl bindings for a project and I thought they were very well done. Previously I had only used the C bindings and taking the step to a higher level language (and more importantly, one with closures) was a very nice step. It was a much better experience than doing Cocoa with Objective-C, IMO, but that could have also been related to the specific (smallish) project I was doing.
It's kind of a domain anti-specific.