Not sure using EC2/AWS/Amazon is a good example here, if you're squeezing for large single-node performance you most certainly go for dedicated servers, or at least avoid vCPUs like a plague.
That site is a bit questionable. I entered "64TB" as the answer and it was very happy to show me a bunch of servers that maxed out at 6 or 8TB. Even the one server that listed 64TB of RAM might be questionable since it's not leaving room for the OS or your applications. That said 64 TB is a gargantuan amount of data, so I'm not too worked up over it not fitting in RAM. Lord help you if you have a power outage and have to reload the data from disk.
Does my data fit in RAM? https://yourdatafitsinram.net/
Not sure using EC2/AWS/Amazon is a good example here, if you're squeezing for large single-node performance you most certainly go for dedicated servers, or at least avoid vCPUs like a plague.