Qubes OS is a niche security-oriented operating system that runs everything in VMs with about 70k users [0]. Even less users contribute with amazing things like running in RAM [1] or using very minimal VMs with Debian and Fedora [3] to minimize the attack surface and bloat.

[0] https://doc.qubes-os.org/en/latest/introduction/statistics.h...

[1] https://forum.qubes-os.org/t/qubes-os-live-mode-dom0-in-ram-...

[2] https://forum.qubes-os.org/t/how-i-learned-to-love-liteqube-...