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Some related studies:

'Partial antagonism of placebo analgesia by naloxone' (http://www.ncbi.nlm.nih.gov/pubmed/6308540) -- no actual morphine was ever adminstered, only a regimen of saline injections, whose placebo effect is apparently achieved by the release of endogenous opioids.

'A comprehensive review of the placebo effect'(http://pharmacology.ucsd.edu/graduate/courseinfo/placebartic...): "placebos have actual biological effects on the brain and body and are more than response biases."



In case you missed it, endocannabinoids (CB1 agonism, in particular) appear to account for the other half of placebo analgesia:

http://www.nature.com/nm/journal/v17/n10/full/nm.2435.html




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