I would give different answers depending on what you're trying to do.

Do you have some data you want to visualize in an interactive way? Maybe try D3.js

Do you want to make 3d models or video games? THREE.js

Do you want to do custom 2D drawings that aren't suited to the previous two? Maybe raw canvas is for you.

Find some comparison tutorials between canvas and either of these, to see just how much more labor-intensive canvas tends to be. Then maybe make a decision as to what to dive deep into first.

Did you mean: > Should I learn d3 or three.js or raw canvas first?