Blade Runner is different because of the attention it received due to the "Final Cut" version that came out in 2007. If it hadn't been for that, references to it would probably be a lot less recognizable with the younger crowd. Case in point: I recently made a "2001: A Space Odyssey" reference in front of a room full of 20-something programmers and not one person picked up on it. It wasn't even that obscure -- it was a picture of the monolith, one of the most recognizable images from the movie (and in science fiction in general). The people in the room generally just hadn't seen or even heard of (really all that is required to get the reference) the movie.

Good luck finding a copy of it with the original film noir-esq voiceover.

It's expensive, but not difficult to find. http://www.amazon.com/Runner-Five-Disc-Complete-Collectors-B... (The version without the voiceover is "the Director's Cut.")

Eh, what's that, you young whippersnapper? In my day we had to debug our difference engine with a flyswatter.