Early in the bootstrapping process, I think it makes sense to go the Github route...make telecommuting and virtual presence a part of your company DNA and then get the best talent::cost ratio by not limiting yourself to employees in any city or state.
Offices in St Louis might be cheaper than San Francisco, but they're nowhere near as cheap as not having an office at all and possibly flying everyone to a common location on a quarterly basis for company all-hands.
Offices in St Louis might be cheaper than San Francisco, but they're nowhere near as cheap as not having an office at all and possibly flying everyone to a common location on a quarterly basis for company all-hands.