Not really - until there's a good Keynote -> JavaScript converter we've got to play the hand that we've been dealt. I actually built one a while back that converted a PDF into a series of images then gave them a simple slideshow:
http://ejohn.org/blog/easy-pdf-sharing/
It worked 'ok' but it didn't maintain any of the embedded links. I kind of gave up since it's an imperfect solution.
I also got my book signed by John, so that was very cool (and John is awesome!)