Lately everything I build with jQuery I will eventually regret it. The first most annoying problem is that events triggered in jQuery cannot be seen by other modules correctly. Even not by another jQuery instance. There is also the usual size problem, when writing reusable code. For example whenever I want to reuse some 100 lines of code on another project I will have to add almost 100kb of jQuery to make it work. Working also on some bigger everlasting projects, like the wysihtml.com editor, has shown that when you need to patch some browser misbehaviours, native javascript is the only way to go. Such patches need to be as close to their error source as possible.